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POEMS syndrome : ウィキペディア英語版 | POEMS syndrome
POEMS syndrome (also known as Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare medical syndrome. It is defined as the combination of a plasma-cell proliferative disorder (typically myeloma), polyneuropathy, and effects on many other organ systems. It begins in middle age – the average age at onset is 50 – and affects up to twice as many men as women.〔 If untreated it is progressive and ==Signs and symptoms== The following are the most common clinical features of POEMS syndrome, either symptoms or signs.〔(【引用サイトリンク】title=Neuromuscular Disease Center, Washington University )〕 The first two are present by definition; the remainder are frequent but not universal, and different individuals experience different combinations of them.
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